Name:
Lipospondin Formula:
C*1H*5N5O4 Molecular:**5 Sequence:
N-Elaidoyl-KFK Purity:≧*5% Grade:
cosmetic Source:
synthetic Stability:
stable Appearance: white
powder MSDS and
COA:available for your
reference Delivery:
promptly from stock 2.Usage: prevent
age-associated dermal alterations 3.Description：N-Elaidoyl-KFK as
well as KFK were shown to activate LAP-TGF-beta both in vitro,
using a solid phase assay with immobilized LAP-TGF-beta, and ex
vivo using human dermal fibroblasts cultures. In both assays, as
much as up to *0% of LAP-TGF-beta added could be recovered as
active form. KQK, KQFK as well as their lipopeptide counterparts
were inactive. Elaidyl-KFK-mediated LAP-TGF-beta activation led to
up-regulation of collagen and TIMP*1 production and down regulation
of PMA-induced MMP*1 expression in fibroblasts cultures. Those
effects could be suppressed by supplementing cell culture medium
with blocking TGF-beta antibody. Elaidyl-KFK inhibited MMP*2,
MMP*9, MMP*3, MMP*1, in vitro with IC(*0) equal to 1.2, 1.0, 0.*4
and 8.9 microM, respectively. Its ex vivo inhibitory capacity, as
assessed using skin tissue sections, towards the elastin-degrading
capacity of MMP*9 was even more pronounced. At a 1 microM
concentration, the lipopeptide decreased by up to *0% enzyme
activity. Thus, "Lipospondin," i.e. elaidyl-KFK might be considered
as a promising model compound to prevent age-associated dermal
alterations.
