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A new life-saving medicine for coronary pneumonia Covid *9



Abi Doll's role in novel coronavirus pneumonia

 

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is a non nucleoside broad-spectrum antiviral drug and a virus fusion blocker



Abidol can interact with the hemagglutinin of the 



virus and prevent the fusion of the virus's lipid and cell membrane, thus inhibiting the release of the virus. Therefore, the novel 



coronavirus can be inhibited by AI, and it can be directly treated with antiviral agents.



2. abidol can improve the level of T cells, B cells and NK cells, and play an important role in regulating immune function



Abidor can 



stimulate cell and humoral immune response: increase the number of lymphocytes in blood, especially T cells (CD3), increase the number of 



T-helper cells (CD4), and do not affect t The level of CD8 normalizes the immune regulation index, stimulates phagocytosis of macrophages 



and increases the number of natural killer cells (NK cells). Therefore, the novel coronavirus pneumonia is also an immunomodulatory agent, 



which may be another important potential for its treatment of new crown pneumonia.



Many literature reports have confirmed that abidor has 



the immunoregulatory effect. The efficacy of abidol in the treatment of influenza and viral respiratory tract infection in children was 



not only in the inhibition of virus, but also in its immunomodulatory effect. At the initial stage of the disease, the cellular immune 



index of all children was significantly reduced. Abidol was used at *0mg/kg/ day dose, and the immune index tended to be normal after 5 



days of treatment. Compared with the control group, T-lymphocyte in abidor group also increased significantly (P < 0.*5), indicating that 



abidol can promote the recovery of T cells and help the immune regulation of the body. The results also showed that abidol could increase 



the number of macrophages and enhance the phagocytosis of macrophages.



The immunomodulatory activity of abidol was studied in cultured 



cells, animals and humans. Abidol has been shown to have an effect on nonspecific defense factors, especially on its ability to induce 



interferon and activate phagocytes. For patients with lower immune baseline, abidol treatment showed that the immune parameters (CD4 and 



CD8 lymphocytes, B-lymphocyte count, serum immunoglobulin level) were improved.



3. abidol can reduce the level of IL*6 isoinflammatory cytokines



Yang Zifeng, the National Key Laboratory of respiratory diseases, 



Guangzhou Medical University, studied the antiviral and anti-inflammatory effects of abidor in vitro and in vivo. The results show that 



abidol can regulate the role of influenza related cytokines and cytokines expression. After three days, the inflammatory factors in the 



trachea and lungs were detected in the ferrets infected with influenza virus. The results showed that several inflammatory cytokines (IL-



*0, tnf- α, IL*8 and IL*6) induced by influenza were down regulated.



4. abidol can induce interferon production

Abidol is an interferon inducer, which can induce the production of interferon, and then induce 



cells to produce many kinds of antiviral proteins, which can interfere with the replication of virus in cells. Studies have shown that 



[7], the interferon titer of volunteers taking abidol is affected by the dose of abidol. The adult volunteers take **0mg abidol orally, 



which can make the interferon titer in serum reach ****0 units / ml; the ingestion of **0mg abidol can cause the rapid increase of 



interferon, with the titer of ******0 units / ml, but the titer of interferon in serum is not more than ****0 units / ml within two days.



Table 2 Effect of abidol on interferon titer in blood of healthy volunteers















In summary, novel coronavirus is a hemagglutinin inhibitor 



(virus fusion inhibitor). Li Lanjuan's team has confirmed that avi can inhibit the novel coronavirus in vitro. Abidol can also induce 



interferon production, and **0mg oral administration can make interferon titer up to ****0 units / ml . At the same time, it can also 



reduce the level of cytokines such as IL*6. In addition, abidor can regulate the immune function of the body, improve the level of T cell 



subsets and B cells, enhance NK cell activity, thus inhibit the transmission of virus in the cell, clear the early malignant cells, and 



effectively prevent the invasion and infection of the virus.