详情
Product Name:Sevoflurane for inhalation
Nombre del Producto:Sevoflurano para inhalacin
Specification: **0ml,**0ml
Package: 1bottle/box
Standard: USP& BP
Therapeutic
indications
Sevoflurane is indicated for induction and maintenance of general
anaesthesia in adult and paediatric patients for inpatient and
outpatient surgery.
Posology and method
of administration
Premedication should be selected according to the need of the
individual patient, and at the discretion of the anaesthetist.
Surgical Anaesthesia:
Sevoflurane should be delivered via a vaporiser specifically
calibrated for use with sevoflurane so that the concentration
delivered can be accurately controlled. MAC (minimum alveolar
concentration) values for sevoflurane decrease with age and with
the addition of nitrous oxide. The table below indicates average
MAC values for different age groups.
Table 1: MAC values for Adults and Paediatric patients according to
age
Age of Patient (years) Sevoflurane in Oxygen Sevoflurane in *5%
N2O/*5% O2
0 1 months* 3.3% 2.0%**
1 - < 6 months 3.0%
6 months - < 3 years 2.8%
3 - *2 2.5%
*5 2.6% 1.4%
*0 2.1% 1.1%
*0 1.7% 0.9%
*0 1.4% 0.7%
* Neonates are full term gestational age. MAC in premature infants
has not been determined.
** In 1 <3 year old paediatric patients, *0% N2O/*0% O2 was
used.
Induction:
Dosage should be individualised and titrated to the desired effect
according to the patient's age and clinical status. A short acting
barbiturate or other intravenous induction agent may be
administered followed by inhalation of sevoflurane. Induction with
sevoflurane may be achieved in oxygen or in combination with
oxygen-nitrous oxide mixtures. In adults inspired concentrations of
up to 5% sevoflurane usually produce surgical anaesthesia in less
than 2 minutes. In children, inspired concentrations of up to 7%
sevoflurane usually produce surgical anaesthesia in less than 2
minutes. Alternatively, for induction of anaesthesia in
unpremedicated patients, inspired concentrations of up to 8%
sevoflurane may be used.
Maintenance:
Surgical levels of anaesthesia may be sustained with concentrations
of 0.5 - 3% sevoflurane with or without the concomitant use of
nitrous oxide.
Emergence:
Emergence times are generally short following sevoflurane
anaesthesia. Therefore, patients may require early post-operative
pain relief.
Older people:
MAC decreases with increasing age. The average concentration of
sevoflurane to achieve MAC in an *0 year old is approximately *0%
of that required in a *0 year old.
Paediatric population:
Refer to Table 1 for MAC values for paediatric patients according
to age.
Contraindications
Sevoflurane should not be used in patients with known or suspected
sensitivity to sevoflurane or other halogenated anaesthetics (e.g.
history of liver function disorder, fever or leucocytosis of
unknown cause after anaesthesia with one of these agents).
Sevoflurane is also contraindicated in patients with known or
suspected genetic susceptibility to malignant hyperthermia.
Sevoflurane is contraindicated in patients in whom general
anaesthesia is contraindicated.
Fertility,
pregnancy and lactation
Pregnancy
Sevoflurane has a relaxant effect on the uterus, which can lead
to increased uterine bleeding, as was reported in a study of its
use during termination of pregnancy. Use during labour and
delivery is limited to one small study in caesarean section.
Reproduction studies in rats and rabbits at doses up to 1 MAC
have revealed no evidence of harm to the fetus due to
sevoflurane. There are no adequate and well-controlled studies in
pregnant women; therefore, sevoflurane should be used during
pregnancy only if clearly needed.
Labour and Delivery
In a clinical trial, the safety of sevoflurane was demonstrated
for mothers and infants when used for anaesthesia during
Caesarean section. The safety of sevoflurane in labour and
vaginal delivery has not been demonstrated.
Breastfeeding
It is not known whether sevoflurane or its metabolites are
excreted in human milk. Due to the absence of documented
experience, women should be advised to skip breast-feeding for *8
hours after administration of sevoflurane and discard milk
produced during this period.
Fertility
Reproduction studies in rats and rabbits at doses up to 1 MAC
have revealed no evidence of impaired fertility due to
sevoflurane.
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Sevoflurane for Inhalation
| 国家: |
China |
| 型号: |
-
|
| 离岸价格: |
50 ~ 60 / Box （面議）
获取最新报价
|
| 位置: |
Shanghai |
| 最小订单价格: |
50 per Box |
| 最小订单: |
1000 Box |
| 包装细节: |
1 bottle per box |
| 交货时间: |
45 days after artworks confirmed |
| 供应能力: |
2000 Box per Day |
| 付款方式: |
T/T |
| 產品組 : |
Central Nervous System
|
