The fully computerized Vogel
Test System is used to monitor the effect of anxiolytic drugs in
small laboratory animals that are water-deprived. They are tested
in special cages featuring a conductive floor grida drinking bottle
with stainless steel nipple connected to a shock generator.
Monitoring of animal licks is performed by very low electrical
currents applied to the nipple that are below the animal''''s
perception level.
After a previously specified number of licks an electric shock is
applied to the nipple - the animal controls the shock frequency by
withdrawing from the drinking tube. Anxiolytic drugs significantly
increase licking ratetherefore number of shocks applied.
Tests the ability of
anxiolytic drugs to disinhibit behavior usually suppressed by
punishment
Can be configured for an
unlimited number of measuring places
