This substance has also been shown to reduce oxidative damage to
DNA in vitro. Scientists exposed cells to *0 micromoles of
naringenin per liter, for *4 hours, and found that the amount of
hydroxyl damage to the DNA was reduced by *4% in that very short
period of time.
Naringenin found in grapefruit juice has been shown to have an
inhibitory effect on the human cytochrome P**0 isoform CYP1A2,
which can change pharmacokinetics in a human (or orthologous) host
of several popular drugs in an adverse manner, even resulting in
carcinogens of otherwise harmless substances.
Naringenin has also been shown to reduce hepatitis C virus
production by infected hepatocytes (liver cells) in cell culture.
This seem to be secondary to Naringenin ability to inhibit the
secretion of very-low-density lipoprotein by the cells. The
antiviral effects of naringenin are currently under clinical
investigation.
Naringenin seems to protect LDLR-deficient mice from the obesity
effects of a high-fat diet.
Naringenin lowers the plasma and hepatic cholesterol concentrations
by suppressing HMG-CoA reductase and ACAT in rats fed a
high-cholesterol diet
