Trama dolforcentralopi oidanal
gesics,there are at leasttwo mechanisms of,Tramadolprototype druganditsmeta bolitesM1 andμ opioidreceptorbinding,andnorepinephrineand 5 -HTreuptakeweakinhibition.Non-steroidalantipyretic analgesicacetaminophen.The exactsite of actionandanal gesic
mechanismis not clear.Theanimal modelstudies have shown thattramadolandacetaminophenused in conjunctionwithsynergies.