Product description:Protamines
are small, arginine-rich, nuclear proteins that replace histones
late in the haploid phase of spermatogenesis and are believed
essential for sperm head condensation and DNA stabilization. They
may allow for denser packaging of DNA in spermatozoon than
histones, but they must be decompressed before the genetic data can
be used for protein synthesis. Genes that are essential for early
embryonic development are still bound to ordinary histones,
comprising about 4 percent of the DNA in
spermatozoons.
Medical Uses:Protamine is used in cardiopulmonary bypass surgery to
neutralize the anti-clotting effects of heparin as well as to
increase pulmonary artery pressure and decrease peripheral blood
pressure, myocardial oxygen consumption, cardiac output, and heart
rate.
