ricin

详情

Ricin (ricin, WA) is a peptide chain having two highly toxic plant proteins. It is mainly present in castor beans.Cas No. :********3
Ricin is extracted from castor plants glycoprotein, molecular weight ****0. Toxins A and B of two polypeptide chains, the chain by one disulfide bond between the two connections. Currently, the amino acid sequence and secondary structure of the A-chain and B chain is basically clear. Or containing two galactose residues of galactose binding sites on the B chain of the toxin, and may contain cell surface galactose residues in receptor binding, into the cytoplasm by retraction action play toxicity. Ricin A, the B-chain and also each contain a two branched sugar chain mannose residues are terminal, can reticuloendothelial cells, especially macrophages binding. The latter is rich in mannose receptor on the cell surface, can be preferentially taken ricin toxin for which play an important role in biological functions