Appearance:Dark
brown to reddish powder Solubility: H2O:
2 mg/mL, clear (warmed); Soluble
in DMSO storage temp: −*0°C
STORAGE It should be protected from light, heat,
oxygen and moisture. Keep container tightly closed.
Once opened, useit quickly.
ADVANTAGES Both superoxide dismutase (SOD)
andcatalase
(CAT) activities Self-regenerating property Smaller molecular weight High stability
RECOMMENDED FOR Skin care (Facial care, Facial cleansing, Body
care, Baby care) Sun care (Sun protection, After-sun &
Self-tanning)
APPLICATIONS Antioxidant UV protection Protect against DNA damage DNA repair Anti-inflammatory Anti-irritation Anti-stress Sunscreen care, supplement the care that
general sunscreen ingredients cant take care of
EUK***4is a
highly purified molecule and a
multi-functional, super antioxidant and powerful free radical
scavenger with self-regenerating property. It is
asyntheticmimetic
of two
natural skin enzymes:catalase
and superoxide dismutase. It protects against free radicals, DNA damages
and reduces erythema and
redness. It helps prevent premature aging and scavenges
superoxide free radicals, eliminates hydrogene peroxide
(H2O2) and
transformsreactive
oxygen species(ROS) into
water and oxygen which are beneficial for the
skin. It protects skin tissue against toxic
compounds, protects skinagainst
UV-induced DNA damage leading to limit premature
photo-aging. It inhibits MMP*2, thus preserving a good ECM
network. It reduces damages caused by UV and skin free
radical activity. It is
used in prevention of DNA damage,repairDNA,brighten
skin tone,anti-irritant, anti-stress, anti-inflammatory,
antioxidant and sun care products. It is complementary to SPF
ingredient.
EUK***4
has dual
antioxidantfunction i.e. superoxide
dismutase and catalase mimetic
activities.Its
therapeutic use and studies conducted are based on its property to
reduce reactive oxygen species (ROS) induced cellular injury in the
body.It
is a low-molecular-weight
synthetic complex
that has better potency,
stability, and bioavailability than
endogenous antioxidant enzymes. EUK-**4can act
as a scavenger for oxidative species such as hydrogen peroxide,
peroxynitrite and superoxide. This compound is a salen-manganese
complex that has been modified to increase its catalase activity
while retaining SOD activity.
EUK***4 has the unique and amazing capacity of
regenerating itself during its free radical scavenging action.
Thereby, EUK***4, represents a complete nature mimetic
antioxidant system that can be used as an active cosmetic
ingredient to limit premature aging, reduce photo-aging, protect
the skin and its DNA from sun damage and decrease
redness.
MECHANISM OF ACTION People consume food
and water every day, transport
them to various body tissues through the digestive system and
circulatory system, and are metabolized in cells to release energy.
During the entire metabolism process, a large number
ofreactive
oxygen species (ROS) will
be produced, including: O2-,
H2O2 and
HO2-,
-OH, etc. TheseROS can
damage the normal cells of the human body, leading to cell
apoptosis and even necrosis. The
two important antioxidant components in the human body are:
superoxide dismutase (SOD) and catalase (CAT). These two components
work closely together to convert the ROS produced in the
metabolic process into water and oxygen to maintain the bodys
normal metabolism. Due
to the high molecular weight of SOD, it is difficult to penetrate
the stratum corneum. In addition, even if SOD enters the skin in a
small amount through pores and sweat glands, it is easily
hydrolyzed by protein and has poor stability and fast metabolism in
the human body. These characteristics of SOD prevent its
application in cosmetics. Therefore, EUK***4 was developed to
replace the application of SOD and CAT in the cosmetics
field. THERAPEUTIC EFFECTS OF
EUK***4 Many inflammatory and
non-inflammatory
diseases, UV rays, pollutants, smoke, and radiation exposure can
cause oxidative damage to the skin. The
synthetic SOD/CATmimetic
EUK***4 might be able to compensate for seasonal deficiencies in
antioxidant defense capacity at the skin surface, protecting the
skin against oxidative damage. EUK***4 is now commercially available as an
antioxidant for the protection of dry or irritated skin. It must
not be used immediately with strong acids such as suspensions
ofascorbicacid.
Strong acids will completely destroy EUK***4 which is based on
manganese. NOTE:
Please avoid
EUK***4 if you have known hypersensitivity to manganese.
Always do a patch test on the upper forearm with the
product to test for possible allergic
reaction.
