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7-hydroxyl Mitragynine

7-hydroxyl Mitragynine

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Product Name: *-hydroxyl Mitragynine
MF: C*3H*0N2O5
MW:**4.***7
CAS:**********7
Description:
*-Hydroxymitragynine is an agonist at the μ-opioid receptor with a potency, calculated using pD values, that is **-fold higher than that of mitragynine and **-fold higher than that of morphine, respectively.  As a partial agonist at this receptor  it causes significantly milder side effects than morphine,  like constipation, development of tolerance and withdrawal syndrome upon abstinence.[2] In murine models, the extracted alkaloids of the Kratom plant are shown to cause an insignificant amount of drug induced respiratory depression, unlike full μ-opioid agonists.  The O-acetyl ester (Acetoxy), *-acetoxymitragynine has also been reported and found to be a weak μ-opioid agonist.

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