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Bulleyaconitine A is a diterpenoid alkaloid that has been isolated
from the Chinese herb, Bulleya. It is a potent κ-opioid receptor
agonist and was found to have cytotoxic effects on rat liver
microsomes. Bulleyaconitine A also has significant
anti-inflammatory properties and inhibits the production of
prostaglandins in vitro. This compound has been shown to induce
apoptosis in cancer cells by inhibiting cyclase activity, which may
be due to its ability to inhibit protein synthesis. In addition,
bulleyaconitine A has been shown to inhibit bone resorption and
promote bone formation, as well as reduce acute toxicities when
administered orally or intraperitoneally. The optimum extraction
process for bulleyaconitine A is an ethanol/water mixture followed
by column chromatography with silica gel or alumina as the
adsorbent material.
