Chloramphenicol

详情

1.Name:Chloramphenicol
2.Cas No.:******7
3.Use:Antibacterial
4.Standards:BP/USP
5.Appearance: A white, grayish-white or yellowish-white, fine, crystalline powder or fine crystals,  needles or elongated plates, slightly soluble in water, freely soluble in alcohol and in  propylene glycol. A solution in ethanol is dextrorotatory and a solution in ethyl acetate is laevorotatory.

6.general info: Chloramphenicol (INN) is a bactericidal antimicrobial. It is considered a prototypical broad-spectrum antibiotic, alongside the tetracycline.
Chloramphenicol is effective against a wide variety of Gram-positive and Gram-negative bacteria, including most anaerobic organisms. Due to resistance and safety concerns, it is no longer a first-line agent for any indication in developed nations, although it is sometimes used topically for eye infections; nevertheless, the global problem of advancing bacterial resistance to newer drugs has led to renewed interest in its use. In low-income countries, chloramphenicol is still widely used because it is exceedingly inexpensive and readily available.
The most serious adverse effect associated with chloramphenicol treatment is bone marrow toxicity, which may occur in two distinct forms: bone marrow suppression, which is a direct toxic effect of the drug and is usually reversible, and a plastic anemia, which is idiosyncratic (rare, unpredictable, and unrelated to dose) and generally fatal.