联系人 Ms. Emily
45-1 Ramsey Road, Shirley, New York
Mutations in the winged-helix transcription factor gene at the nude
locus in mice and rats produce the pleiotropic phenotype of
hairlessness and athymia, resulting in a severely compromised
immune system. This gene is orthologous to the mouse and rat genes
and encodes a similar DNA-binding transcription factor that is
thought to regulate keratin gene expression. A mutation in this
gene has been correlated with T-cell immunodeficiency, the skin
disorder congenital alopecia, and nail dystrophy. Alternative
splicing in the 5' UTR of this gene has been observed.
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