MitoQ

详情

MitoQ
 

Synonym: Mitoquinone mesylate, MitoQ*0, Mitoubiquinone mesylate, Mitoquinone methanesulfonate,

CAS No.: **********4

Molecular Formula: C*8H*7O7PS

Molecular Weight: **8.*1

Description: MitoQ comprises a lipophilic triphenylphosphonium (TPP) cation covalently linked by an aliphatic **-carbon chain to an antioxidant ubiquinone moiety. The TPP lipophilic cation passes rapidly through biological membranes and its positive charge drives the extensive accumulation of these molecules into mitochondria, due to the large mitochondrial membrane potential. The ubiquinone moiety is activated and recycled by complex II within mitochondria and acts as a chain breaking antioxidant to prevent oxidative damage. This combination of extensive uptake into mitochondria, recycling of the antioxidant moiety and its location on the matrix facing surface of the mitochondrial inner membrane makes MitoQ many thousand fold more potent at preventing oxidative damage than untargeted antioxidants. MitoQ has been used extensively in animal models of human pathologies where it has been shown to be effective following oral, intravenous or intraperitoneal delivery. In addition, MitoQ has been used in two Phase II trials in humans and been shown to be safe and well tolerated long term and effective at preventing liver inflammatory damage in a small study of hepatitis C virus-patients.

Package: *0Gram, **0Gram, 1KG.