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Zearalenone is rapidly absorbed following ingestion and is metabolized by the liver, intestinal mucosa, and gut microflora of pigs into the toxic metabolites α and β-zearalenol and the glucuronide conjugates of both compounds. α-zearalenol has about three-fold more estrogenic potency than zearalenone.

Zearalenone and its metabolites have been found in the plasma of a pig less than *0 minutes after consumption. The gastrointestinal uptake in swine after a single oral dose of *0 mg/kg body weight has been estimated to be *0 to *5%. Zearalenone and its metabolites are excreted in the feces, most within *2 hours of ingestion. Extensive cycling of zearalenone and its metabolites via enterohepatic circulation increases its biological half life significantly extending toxic exposure.

Calibrin-Z quickly adsorbs mycotoxins and significantly reduces gastrointestinal uptake. Sequestering the toxins in the intestinal lumen so they are not absorbed reduces the animal's exposure by a factor of *5.