Mafodotin, also known as mc-MMAF and SGD****9 or Maleimidocaproyl
monomethylauristatin F, is a MMAF derivative having a
Maleimidocaproyl linker (MC linker), which is ready to conjugate to
antibody or other proteins or biopolymers. Mafodotin is a useful
agent for make antibody drug conjugate (ADC) for targeted drug
delivery. MMAF is a potent antimitotic and antitublin auristatin
derivative with a charged C-terminal phenylalanine residue that
attenuates its cytotoxic activity compared to its uncharged
counterpart, MMAE.
